Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Take Zyprexa exactly as prescribed. Your doctor may need to change adjust the dose of Zyprexa until it is right for you. Concomitant administration of intramuscular olanzapine and parenteral benzodiazepine is not recommended due to the potential for excessive sedation and cardiorespiratory depression. ikni.info loratadine
These serious side effects are described below. This list is not complete and other drugs may interact with olanzapine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. There are 2 types of injection short- and long-acting. These 2 forms have different uses and dosing and the 2 products are not interchangeable. It is not known if Zyprexa Relprevv is safe and effective in children under 18 years of age. If you are taking a combination of drugs, use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Most neuroleptic agents have anticholinergic activity, to which elderly patients are particularly sensitive. Clozapine and low-potency agents such as chlorpromazine and thioridazine tend to exhibit the greatest degree of anticholinergic effects in the class, while haloperidol as well as the newer, atypical agents like quetiapine, risperidone and ziprasidone have generally been associated with very low frequencies of anticholinergic adverse effects. Therapy with neuroleptic agents should be administered cautiously in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders.
Hyperglycemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported with the use of atypical antipsychotic agents. Patients with diabetes should be monitored for worsening control of blood glucose when treated with these agents. It is recommended that patients with risk factors for diabetes mellitus starting treatment with atypical antipsychotics should undergo fasting blood glucose testing at the beginning of treatment, and periodically thereafter. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. In some cases, hyperglycemia has resolved when treatment with these agents was discontinued; however, some patients required continuation of anti-diabetic treatment despite discontinuation of the atypical antipsychotic drug.
Since olanzapine has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that olanzapine therapy does not affect them adversely. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. This long-acting form of injection may cause serious side effects, including severe drowsiness, inability to wake up and confusion delirium after injection. Skullcap is a plant. The above ground parts are used to make medicine. The primary efficacy measure used for assessing agitation signs and symptoms in these trials was the change from baseline in the PANSS Excited Component at 2 hours post-injection. Patients could receive up to 3 injections during the 24 hour IM treatment periods; however, patients could not receive the second injection until after the initial 2 hour period when the primary efficacy measure was assessed. This medication may contain aspartame.
This medication is given by injection into the buttock muscle by a professional as directed by your doctor, usually every 2 to 4 weeks. In postmarketing reports of overdose with olanzapine alone, symptoms have been reported in the majority of cases. Atypical antipsychotic drugs have been associated with metabolic changes including hyperglycemia, dyslipidemia, and weight gain. Bent or damaged needles can result in breakage or damage to the tissue or accidental needle puncture. When using Zyprexa and fluoxetine in combination, the prescriber should also refer to the Warnings and Precautions section of the package insert for Symbyax. protonix
The chemicals in skullcap might work by preventing swelling . Other chemicals in skullcap are thought to cause sedation drowsiness. Call your doctor or contact a poison control center immediately. Do not induce vomiting unless advised to do so by a trained medical professional. Some MEDICINES MAY INTERACT with Zyprexa Intramuscular. Patients with the following COSTART terms were counted in this category: akathisia, hyperkinesia. For deep intramuscular gluteal injection only. Not to be injected intravenously or subcutaneously. Clinical studies of Zyprexa Relprevv did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In the premarketing clinical studies with oral olanzapine, there was no indication of any different tolerability of olanzapine in elderly patients compared to younger patients with schizophrenia. Oral olanzapine studies in elderly patients with dementia-related psychosis have suggested that there may be a different tolerability profile in this population compared to younger patients with schizophrenia. Elderly patients with dementia-related psychosis treated with olanzapine are at an increased risk of death compared to placebo. Food and Drug Administration. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. The presence of other medical problems may affect the use of this medicine. Zyprexa powder for solution for injection is indicated for the rapid control of agitation and disturbed behaviours in patients with schizophrenia or manic episode, when oral therapy is not appropriate. Treatment with Zyprexa powder for solution for injection should be discontinued and the use of oral olanzapine should be initiated as soon as clinically appropriate. What is Zyprexa? The European Commission granted a marketing authorisation valid throughout the European Union for Zyprexa on 27 September 1996.
Shake the vial vigorously until the suspension appears smooth and is consistent in color and texture. Dose group differences with respect to weight gain have been observed in some studies. This medicine may cause tardive dyskinesia a movement disorder. Check with your doctor right away if you or your child have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs. Drug Reaction with Eosinophilia and Systemic Symptoms DRESS hepatitis, jaundice, neutropenia, pancreatitis, priapism, rash, restless legs syndrome, rhabdomyolysis, and venous thromboembolic events including pulmonary embolism and deep venous thrombosis. ZYDIS is a registered trademark of Catalent Pharma Solutions. Ask your healthcare professional how you should dispose of any medicine you do not use. Do not stop taking any medications without consulting your healthcare provider. For fasting HDL cholesterol, no clinically meaningful differences were observed between olanzapine-treated adolescents and placebo-treated adolescents. The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses or may even arise after discontinuation of treatment. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Patients with the following COSTART terms were counted in this category: buccoglossal syndrome, choreoathetosis, dyskinesia, tardive dyskinesia. Placental transfer of olanzapine occurs in rat pups. In patients whose manic episode has responded to olanzapine treatment, olanzapine is indicated for the prevention of recurrence in patients with bipolar disorder. In analyses of patients who completed 9-12 months of olanzapine therapy, mean change in fasting and nonfasting glucose levels continued to increase over time. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. order imiquimod capsules
If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Contact your doctor right away if you think you may be dehydrated. Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking Zyprexa as monotherapy or in combination with fluoxetine. If you do not think you are getting better or have any concerns about your condition while taking Zyprexa, call your doctor. When using Zyprexa and fluoxetine in combination, also refer to the Patient Counseling Information section of the package insert for Symbyax. Olanzapine has not been systematically studied in humans for its potential for abuse, tolerance, or physical dependence. An increase in mammary gland neoplasms has been found in rodents after chronic administration of other antipsychotic drugs and is considered to be prolactin mediated. The physician should periodically reexamine the need for continued pharmacotherapy. If you notice any of these symptoms in your especially during their first month, tell the doctor right away.
It is not known if Zyprexa Relprevv will harm your unborn baby. Weight gain. Weight gain is very common in people who take Zyprexa Relprevv. Teenagers 13 to 17 years old are more likely to gain weight and to gain more weight than adults. Zyprexa Relprevv is not approved in patients less than 18 years old. Some people may gain a lot of weight while taking Zyprexa Relprevv, so you and your doctor should check your weight regularly. Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet, and exercising. LILLY and tablet number. Hypodermic Needle-Pro needle with needle protection device. Olanzapine is well absorbed and reaches peak concentrations in approximately 6 hours following an oral dose. It is eliminated extensively by first pass metabolism, with approximately 40% of the dose metabolized before reaching the systemic circulation. Food does not affect the rate or extent of olanzapine absorption. Pharmacokinetic studies showed that Zyprexa tablets and Zyprexa ZYDIS olanzapine orally disintegrating tablets dosage forms of olanzapine are bioequivalent. Hyperprolactinemia may suppress hypothalamic GnRH, resulting in reduced pituitary gonadotropin secretion. This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds. Long-standing hyperprolactinemia when associated with hypogonadism may lead to decreased bone density in both female and male subjects. If the product is not used right away, it should be shaken vigorously to re-suspend. Mean increases in fasting lipid values total cholesterol, LDL and triglycerides were greater in patients without evidence of lipid dysregulation at baseline. Dose group differences with respect to prolactin elevation have been observed. Infrequent: creatine phosphokinase increased. CBC monitored frequently during the first few months of therapy and discontinuation of Zyprexa should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors. The information contained in the Truven Health Micromedex products as delivered by Drugs. Patients with the following MedDRA terms were counted in this category: lower respiratory tract infection, respiratory tract infection, respiratory tract infection viral, upper respiratory tract infection, viral upper respiratory tract infection. There were confounding factors that may have contributed to the occurrence of seizures in many of these cases. The safety and efficacy of olanzapine have not been established in patients under the age of 13 years. Seizures: Tell your doctor if you have a seizure during treatment with Zyprexa Relprevv. warticon price philippines
Zyprexa can cause sleepiness and may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how Zyprexa affects you. Zyprexa tablets are intended for oral administration only. HCl is a fixed-dose combination of ZYPREXA and fluoxetine. This medicine may increase your weight. Your doctor may need to check your or your child's weight on a regular basis while you are using this medicine. Olanzapine may antagonize the effects of levodopa and dopamine agonists.
It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. ZYPREXA monotherapy is not indicated for treatment of treatment resistant depression major depressive disorder in patients who do not respond to 2 antidepressants of adequate dose and duration in the current episode. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Zyprexa Relprevv is a long-acting form of olanzapine and is intended for deep intramuscular gluteal injection only. Zyprexa Relprevv is indicated for the treatment of schizophrenia. ZYPREXA monotherapy is not indicated for the treatment of depressive episodes associated with bipolar I disorder. What happens if I miss a dose Zyprexa, Zyprexa Zydis? Injection site abscess has been reported in clinical trials with Zyprexa Relprevv therapy. Isolated cases required surgical intervention. Patient and caregivers should be advised that after each Zyprexa Relprevv injection, patients must be observed at the healthcare facility for at least 3 hours and must be accompanied to their destination upon leaving the facility. The Medication Guide should be distributed each time patients receive an injection. Khan, I. A. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat. Use Zyprexa Intramuscular as directed by your doctor. Check the label on the medicine for exact dosing instructions. Deaths did not appear to be associated to the dose of the drug they were taking or the duration of use. Use this medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you need to receive the medication. Zyprexa Relprevv Patient Care Program. You must agree to the rules of the Zyprexa Relprevv Patient Care Program before you register. Frequent: alkaline phosphatase increased; Infrequent: bilirubinemia, hypoproteinemia. deltasone
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. PDSS. When you leave the clinic someone must be with you. If you have symptoms of PDSS after you leave the clinic, get medical help or go to an emergency room right away. Patent and Trademark Office and certain other countries. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Infrequent: amenorrhea 2, breast pain, decreased menstruation, impotence 2, increased menstruation 2, menorrhagia 2, metrorrhagia 2, polyuria 2, urinary frequency, urinary retention, urinary urgency, urination impaired. Approximately 57% and 30% of the dose was recovered in the urine and feces, respectively. In the plasma, olanzapine accounted for only 12% of the AUC for total radioactivity, indicating significant exposure to metabolites. Loosen the powder by lightly tapping the vial. These terms represent serious adverse events but do not meet the definition for adverse drug reactions. They are included here because of their seriousness. Use Zyprexa Intramuscular with caution in the ELDERLY; they may be more sensitive to its effects. Dose group differences with respect to weight gain have been observed. If you have any questions about Zyprexa Intramuscular, please talk with your doctor, pharmacist, or other health care provider.
High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Be aware that there are two ZYPREXA intramuscular formulations with different dosing schedules. Based on a search of the following terms: breast discharge, enlargement or swelling, galactorrhea, gynecomastia, and lactation disorder. Dystonia, Class Effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Olanzapine can be taken with or without food. What are some ways to get the most out of my treatment with this medication? lotriderm cost south africa
F that are experienced in pharmacies, hospitals, and warehouses. DO NOT INJECT INTRAVENOUSLY OR SUBCUTANEOUSLY. While these symptoms can occur at low doses, the frequency and severity are greater with high potency and at higher doses of first generation antipsychotic drugs. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically. SOME EXCESS PRODUCT WILL REMAIN IN THE VIAL. Read the Medication Guide that comes with Zyprexa before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your doctor about your medical condition or treatment. Talk with your doctor or pharmacist if there is something you do not understand or you want to learn more about Zyprexa. If you have a history of heart disease, heart failure, irregular heartbeat, high or low blood pressure, stroke, or seizures you should talk to your doctor before you take this medication. Tell your doctor if you or anyone in your family currently has or has ever had diabetes.
Compared to patients from adult clinical trials, adolescents treated with oral ZYPREXA were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin and hepatic aminotransferase levels. Oral olanzapine should be administered in combination with fluoxetine once daily in the evening, without regard to meals, generally beginning with 5 mg of oral olanzapine and 20 mg of fluoxetine. For specific information about overdosage with lithium or valproate, refer to the Overdosage section of the package inserts for these products. For specific information about overdosage with olanzapine and fluoxetine in combination, refer to the Overdosage section of the Symbyax package insert. Tell your doctor about all the medicines that you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Zyprexa and some medicines may interact with each other and may not work as well, or cause possible serious side effects. Your doctor can tell you if it is safe to take Zyprexa with your other medicines. Do not start or stop any medicine while taking Zyprexa without talking to your doctor first. The stated frequencies of adverse reactions represent the proportion of individuals who experienced, at least once, a treatment-emergent adverse reaction of the type listed. A reaction was considered treatment emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation. The reported reactions do not include those reaction terms that were so general as to be uninformative. Reactions listed elsewhere in labeling may not be repeated below. It is important to emphasize that, although the reactions occurred during treatment with olanzapine, they were not necessarily caused by it. The entire label should be read to gain a complete understanding of the safety profile of olanzapine. While there is no body of evidence to answer the question of how long a patient treated with Zyprexa and fluoxetine in combination should remain on it, it is generally accepted that treatment resistant depression major depressive disorder in adult patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode is a chronic illness requiring chronic treatment. The physician should periodically reexamine the need for continued pharmacotherapy. Olanzapine is effective in maintaining the clinical improvement during continuation therapy in patients who have shown an initial treatment response. Smiths Medical ASD, Inc. EPS. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system pathology. generic famciclovir from north carolina
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For some patients, this medicine can increase thoughts of suicide. Tell your doctor right away if you or your child start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Make sure the doctor knows if you or your child have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder manic-depressive illness or has tried to commit suicide. coreg
Seizures: Tell your doctor if you have a seizure during treatment with Zyprexa. The most common side effects with Zyprexa seen in more than 1 patient in 10 are somnolence sleepiness weight gain, orthostatic hypotension sudden drop in blood pressure on standing up and raised levels of prolactin a hormone. For the full list of all side effects reported with Zyprexa, see the package leaflet. Open the sachet and peel back the foil on the blister. Do not push the tablet through the foil. Olanzapine displays linear kinetics over the clinical dosing range. Tolerance of oral ZYPREXA should be established prior to initiating treatment with Zyprexa Relprevv.
This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one. Olanzapine clearance is about 40% higher in smokers than in nonsmokers, although dosage modifications are not routinely recommended. None of these patients experienced jaundice or other symptoms attributable to liver impairment and most had transient changes that tended to normalize while Zyprexa Relprevv treatment was continued. For both oral ZYPREXA and Zyprexa Relprevv, studies have demonstrated that the clearance of olanzapine is higher in smokers than in nonsmokers, although dosage modifications are not routinely recommended.
What should I avoid while receiving Zyprexa Relprevv? Overall, there was no difference in the incidence of discontinuation due to adverse reactions 2% for oral olanzapine vs 2% for placebo. Since these neurotransmitters are involved in schizophrenia and in bipolar disorder, olanzapine helps to normalise the activity of the brain, reducing the symptoms of these diseases. How has Zyprexa been studied? There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.